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1

Bis-aryl triazoles as selective inhibitors of 11β-hydroxysteroid dehydrogenase type 1

Susan D. Aster, Donald W. Graham, Divya Kharbanda, Gool Patel, Mitree Ponpipom, Gina M. Santorelli, Michael J. Szymonifka, Steven S. Mundt, Kashmira Shah, Marty S. Springer, Rolf Thieringer, Anne Herm

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2008

Language:

english

File:

PDF, 302 KB

english, 2008

2

4,7.beta.-Dimethyl-4-azacholestan-3-one (MK-386) and Related 4-Azasteroids as Selective Inhibitors of Human Type 1 5.alpha.-Reductase

Bakshi, Raman K., Patel, Gool F., Rasmusson, Gary H., Baginsky, Walter F., Cimis, George, Ellsworth, Kenneth, Chang, Benedict, Bull, Herb, Tolman, Richard L., Harris, Georgianna S.

Journal:

Journal of Medicinal Chemistry

Year:

1994

Language:

english

File:

PDF, 446 KB

english, 1994

3

4-Methyl-3-oxo-4-aza-5α-androst-1-ene-17β-N-aryl-carboxamides: an approach to combined androgen blockade [5α-reductase inhibition with androgen receptor binding in vitro]

Tolman, Richard L., Sahoo, Soumya P., Bakshi, Raman K., Gratale, Dominick, Patel, Gool, Patel, Sushma, Toney, Jeffrey, Chang, Benedict, Harris, Georgianna S.

Journal:

The Journal of Steroid Biochemistry and Molecular Biology

Year:

1997

Language:

english

File:

PDF, 634 KB

english, 1997

4

Total synthesis of (.+-.)-1-carbacefoxitin and -cefamandole and (.+-.)-1-oxacefamandole

Firestone, Raymond A., Fahey, John L., Maciejewicz, Natalie S., Patel, Gool S., Christensen, B. G.

Journal:

Journal of Medicinal Chemistry

Year:

1977

Language:

english

File:

PDF, 826 KB

english, 1977

5

Phenylcyclobutyl triazoles as selective inhibitors of 11β-hydroxysteroid dehydrogenase type I

Yuping Zhu, Steven H. Olson, Donald Graham, Gool Patel, Anne Hermanowski-Vosatka, Steven Mundt, Kashmira Shah, Marty Springer, Rolf Thieringer, Samuel Wright, Jianying Xiao, Hratch Zokian, Jasminka Dr

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2008

Language:

english

File:

PDF, 292 KB

english, 2008

6

4-Aza-3-oxo-5.alpha.-androst-1-ene-17.beta.-N-arylcarboxamides as Dual Inhibitors of Human Type 1 and Type 2 Steroid 5.alpha.-Reductases. Dramatic Effect of N-Aryl Substituents on Type 1 and Type 2 5.alpha.-Reductase Inhibitory Potency

Bakshi, Raman K., Rasmusson, Gary H., Patel, Gool F., Mosley, Ralph T., Chang, Benedict, Ellsworth, Kenneth, Harris, Georgianna S., Tolman, Richard L.

Journal:

Journal of Medicinal Chemistry

Year:

1995

Language:

english

File:

PDF, 1.32 MB

english, 1995

7

4-Aza-3-oxo-5α-androst-1-ene-17β- N -arylcarboxamides as Dual Inhibitors of Human Type 1 and Type 2 Steroid 5α-Reductases. Dramatic Effect of N -Aryl Substituents on Type 1 and Type 2 5α-Reductase Inhibitory Potency

Bakshi, Raman K., Rasmusson, Gary H., Patel, Gool F., Mosley, Ralph T., Chang, Benedict, Ellsworth, Kenneth, Harris, Georgianna S., Tolman, Richard L.

Journal:

Journal of Medicinal Chemistry

Year:

1996

File:

PDF, 44 KB

1996

8

Azasteroids: structure-activity relationships for inhibition of 5.alpha.-reductase and of androgen receptor binding

Rasmusson, Gary H., Reynolds, Glenn F., Steinberg, Nathan G., Walton, Edward, Patel, Gool F., Liang, Tehming, Cascieri, Margaret A., Cheung, Anne H., Brooks, Jerry R., Berman, Charles

Journal:

Journal of Medicinal Chemistry

Year:

1986

Language:

english

File:

PDF, 2.22 MB

english, 1986

9

Synthesis and antiherpetic activity of (.+-.)-9-[[(Z)-2-(hydroxymethyl)cyclopropyl]methyl]guanine and related compounds

Ashton, Wallace T., Meurer, Laura Canning, Cantone, Christine L., Field, A. Kirk, Hannah, John, Karkas, John D., Liou, Richard, Patel, Gool F., Perry, Helen C.

Journal:

Journal of Medicinal Chemistry

Year:

1988

Language:

english

File:

PDF, 1.60 MB

english, 1988

10

Design and synthesis of novel antibacterial agents with inhibitory activity against DNA polymerase III

Amjad Ali, Susan D Aster, Donald W Graham, Gool F Patel, Gayle E Taylor, Richard L Tolman, Ronald E Painter, Lynn L Silver, Katherine Young, Kenneth Ellsworth, Wayne Geissler, Georgianna S Harris

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2001

Language:

english

File:

PDF, 210 KB

english, 2001

11

Novel ketal ligands for the glucocorticoid receptor: in vitro and in vivo activity

Cameron J. Smith, Amjad Ali, James M. Balkovec, Donald W. Graham, Milton L. Hammond, Gool F. Patel, Gregory P. Rouen, Scott K. Smith, James R. Tata, Monica Einstein, Lan Ge, Georgianna S. Harris, Ther

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 234 KB

english, 2005

12

A new fluorogenic substrate for chymotrypsin

Morris Zimmerman, Edward Yurewicz, Gool Patel

Journal:

Analytical Biochemistry

Year:

1976

Language:

english

File:

PDF, 259 KB

english, 1976

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